Je vous remet ici un passage d'une interview de Guillermo Del Toro sur le sujet, trouvé sur Cartoon Brew.

I really wanted to land the connections between the [show’s] set pieces and the titles and some of the most iconic horror movies, and intersperse them with some of my stuff in there for pure joy. For example the idea that Ms. Krabappel could be outside the school with Alfred Hitchcock which is a reference to the sequence inThe Birds that happens outside of the school in Bodega Bay. To use Chief Wiggum as the Cyclops from Harryhausen, dipping the [Lard Lad] donut in a water tank, to have the nuclear spill from Mr. Burns’ plant create zombies — all of this stuff seems to make sense to interconnect. If Homer really gets a radioactive isotope, he could turn into a reaper from Blade. Or the famous shot that is always in the titles — Maggie driving and then you pull back and there’s Marge driving, right? But in this case Maggie is driving, and she’s driving the car from the horror movie from the 70s called The Car,which is one of my favorite guilty pleasure B-movies. And what if Lisa is in the music class, but she’s in the music class with every Phantom of the Opera ever made? It was a unique opportunity.

Et pour rappel, il n'est pas le seul à avoir saisit cette fameuse "unique opportunity" qu'offre la possibilité d'avoir carte blanche pour faire un générique des Simpsons. 

Voici le générique fait par Banksy, il y a environ 3 ans :

( bien plus hardcore il faut l'avouer. )